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KMID : 0869420130110010015
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Journal of Jeahan Oriental Medical Academy
2013 Volume.11 No. 1 p.15 ~ p.25
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The study on chemical compound and traditional medical effect of Bupleurum falcatum L
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Jung Sung-Hyo
Roh Seong-Soo
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Abstract
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Objects: This study was conducted to investigate the pharmacological effect and its chemical compound in Bupleurum falcatum L.
Methods: First, we searched books, research paper, internet site. Second, we researched keyword: Bupleurum flacatum, effect, chemical, compound, extract, saikosaponin A, Bl, B2, B3, B4, C, D, el, H, I, a-spinasterol, stigmasterol, bupleurmol, eugenol, hexoic, v-lactone undecylate, p-methoxy phenyl diketone, olecic acid, linolenic acid, palmitic acid, stearic acid, polysaccharide, alkaloids, glucose, amino acid. Third, Keywords arrangement a pharmacological effects extract of Bupfeurum fi1fcatum, chemical compound of Bupleurum falcatum, fraction of Bupleurum falcatum.
Results: First Pharmacological action of the crude extract of Bupleurum anti-foam ceil formation, hypothyroidism improvement, improvement of ischemic stroke symptoms, inhibited acute lung injury, anti-inflammatory bowel disease, damage to the sciatic nerve axon regeneration Crush improvement action is reactive. The second, Bupleurum falcatum extract fractions have VCAM-l/VLA-4 inhibitory effect, liver damage recovery effects. Third, Bupleurum falcatum pharmacological efficacy of the ingredients of the GABA-B receptor through reducing the reinforcing effects of morphine, liver damage, depression, suppression of urine protein excretion, increased serum cholesterol, inhibit the increase of serum corticosterone, hamam effects in osteoarthritis cartilage damage reduction, improvement of blood lipid peroxidation and liver damage has been reported suppression. Fourth, Bupleurum falcatum of beneficient an oriental sympotom are inhibit liver damage, ischemic stroke improvement, anti-inflammatory bowel disease is suppressed.
Conc1usion: These chemical compounds and extract of Bupleurum falcatum L. may be used several disease. The effect of gangiwoolkeol and talhang can be explained, but others were insufficient data available on efficacy. Furthermore, resear.ch is need.
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KEYWORD
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Bupleurum falcatum L, chemical compound, saikosaponin, stigmasterol, eugenol, extract fraction
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